A. Ricinelaidic acid. Ricinoleic acid (Note 1) (39.75 g, 0.106 mol) and 586 mg (2 mol %) of diphenyl disulfide dissolved in 1000 mL of hexane are placed in a photochemical reactor (Note 2) and irradiated for 3 hr with a Philips HP(L) 250-W medium-pressure mercury lamp. After irradiation the solvent is removed under reduced pressure and the semisolid residue is recrystallized from 185 mL of hexane to yield 11.3 g of crude ricinelaidic acid, mp 39–43°C. The irradiation is repeated with the mother liquor under the same conditions to yield, after removal of the solvent and recrystallization of the residue from 135 mL of hexane, an additional 7.2 g, mp 38–42°C; total yield of crude ricinelaidic acid is 18.5 g (58%). The product after recrystallization from 220 mL of hexane weighs 15.6 g (49%), mp 43–45°C, and is suitable for the following step. Repeated recrystallization from hexane yields ricinelaidic acid with mp 51.0–51.5°C (Note 3) and (Note 4).

B. Ricinelaidic acid S-(2-pyridyl)carbothioate. In a dry, stoppered, 10-mL flask containing a magnetic stirring bar are placed 360 mg (1.2 mmol) of ricinelaidic acid (see above), 308 mg (1.4 mmol) of 2,2'-dipyridyl disulfide (Note 5), 1 mL of benzene, and 367 mg (1.4 mmol) of triphenylphosphine, and the mixture is stirred for 30 min. The resulting slurry is then dissolved in 55 mL of dry acetonitrile (Note 6).

C. Ricinelaidic acid lactone. Dry acetonitrile (100 mL), 3.5 mL of 1 M silver perchlorate in toluene (Note 7) and (Note 8), and a magnetic stirring bar are placed in a 500-mL flask equipped with a reflux condenser that carries a Hershberg dropping funnel. The solution is heated in an oil bath so that the boiling acetonitrile returns from the condenser at the rate of 5–10 drops per second (Note 9). Then the acetonitrile solution of the ricinelaidic acid S-(2-pyridyl)carbothioate is added dropwise during 1 hr through the condenser to the magnetically stirred refluxing silver perchlorate solution (Note 9). The slightly turbid mixture is boiled for an additional 15 min and the solvent is removed under reduced pressure in a rotary evaporator. The residue is diluted with 30 mL of 0.5 M potassium cyanide solution and the mixture containing suspended solids is extracted with three 50-mL portions of benzene. The benzene extracts are washed with 30 mL of water, dried with anhydrous magnesium sulfate, and filtered, and the solvent is removed under reduced pressure. Crude product is obtained as an oil (710 mg). It can be purified by chromatography on 40 g of silica gel (Note 10) with benzene as eluant. Fractions of 10 mL are collected at 30-min intervals. Fractions 7–19 contain 283–296 mg (84–88%) of ricinelaidic acid lactone (Note 11).