OS Perspectives provide authors with an opportunity to provide personal perspectives on topics associated with the field of organic synthesis. Appropriate subjects for OS Perspectives include, but are not limited to, discussions of the following:

• Trends and developments in strategies, methods, and the applications of organic synthetic chemistry
• Trends and developments with regard to the community of researchers in the field
• Reflections on how research in the field is carried out and published
• Perspectives discussing reproducibility in synthetic chemistry are particularly welcome
• Also welcome are Perspectives on the role and value of the publication Organic Syntheses including personal reminiscences.

Typical Perspectives are expected to be on the order of 2-20 published pages in length.

Perspectives should follow the style guidelines used for organic chemistry articles published in the ACS journals such as J. Am. Chem. Soc., J. Org. Chem., Org. Lett., etc. as described in the ACS Style Guide (3^rd Ed.) and https://pubs.acs.org/page/acsguide . The text of the Perspective should be created using the Word template available on the Organic Syntheses website. Specific instructions with regard to the manuscript format (font, spacing, margins) is available on the website in the "Instructions for Perspectives Template" and embedded within the Perspective Template itself.

Chemical structures and schemes should be drawn using the standard ACS drawing parameters (in ChemDraw, the parameters are found in the "ACS Document 1996" option) with a maximum full size width of 15 cm (5.9 inches). The graphics files should then be pasted into the Word document at the correct location and the size reduced to 75% using "Format Picture" (Mac) or "Size and Position" (Windows). Graphics files must also be submitted separately. All Tables that include structures should be entirely prepared in the graphics (ChemDraw) program and inserted into the word processing file at the appropriate location. Tables that include multiple, separate graphics files prepared in the word processing program will require modification.

Tables and schemes should be numbered and should have titles. The title for a Table should be placed immediately above the table. The title for a scheme should be placed immediately below the scheme. Use 10 point Palatino Bold font in the ChemDraw file for all titles. For footnotes in Tables use Helvetica (or Arial) 9 point font and place these immediately below the Table.

References to prior literature included as footnotes should follow the current style requirements of JACS and should include the titles of articles. Inclusion of DOIs with each reference is strongly encouraged.

Authors are welcome to include photographs in Perspectives. Photographs should be inserted into articles at the place in the text and Notes where they are first referred to and should be numbered and labeled as Figures with descriptive titles. See the general Instructions for Authors for Organic Syntheses articles for more information.

Contact information (institution and mailing address for the principal author) should be included as footnote 1. This footnote should also include the email address and ORCID for the principal author. Acknowledgment of financial support should be included in footnote 1.

Photographs and 100-word biographies of all authors should be submitted as separate files at the time of the submission of the procedure. The format of the biographies should be similar to those in articles that can be viewed on the orgsyn.org website. Photographs can be accepted in a number of electronic formats, including tiff and jpeg formats.