Discussion Addenda provide authors of previously published Organic Syntheses articles with an opportunity to update and expand on the discussion section of those articles. The original articles and Discussion Addenda are electronically linked on the Organic Syntheses website so that readers are alerted to the publication of an addendum when accessing the original article.

Appropriate subjects for Discussion Addenda include the following. (a) Further discussion of the scope and utility of the chemistry reported in the original article, especially in the context of further advances since the original publication of the Organic Syntheses article. (b) References to related work and applications of the chemistry that have appeared since the original Organic Syntheses publication. Discussions of applications need not be exhaustive and should focus on examples that illustrate important features of the chemistry or that extend the scope of the chemistry. (c) Additional practical suggestions concerning optimal conditions for reactions, the purification of reagents, etc. Note, however, that Discussion Addenda should not include full experimental procedures.

Typical Discussion Addenda are expected to be on the order of 5-15 published pages in length, and should not exceed 20 pages (including references, but not including the photos and biographies of authors). Authors may find it useful to review published examples of Discussion Addenda which can be viewed on the Organic Syntheses website beginning with Volume 88.

Articles should follow the style guidelines used for organic chemistry articles published in the ACS journals such as J. Am. Chem. Soc., J. Org. Chem., Org. Lett., etc. as described in the ACS Style Guide (3^rd Ed.). The text of the procedure should be created using the Word template available on the Organic Syntheses website. Specific instructions with regard to the manuscript format (font, spacing, margins) is available on the website in the “Instructions for Article Template” and embedded within the Article Template itself.

Chemical structures and schemes should be drawn using the standard ACS drawing parameters (in ChemDraw, the parameters are found in the “ACS Doci Chuckument 1996” option) with a maximum full size width of 15 cm (5.9 inches). The graphics files should then be pasted into the Word document at the correct location and the size reduced to 75% using “Format Picture” (Mac) or “Size and Position” (Windows). Graphics files must also be submitted separately. All Tables that include structures should be entirely prepared in the graphics (ChemDraw) program and inserted into the word processing file at the appropriate location. Tables that include multiple, separate graphics files prepared in the word processing program will require modification.

Tables and schemes should be numbered and should have titles. The title for a Table should be placed immediately above the table. The title for a scheme should be placed immediately below the scheme. Use 10 point Palatino Bold font in the ChemDraw file for all titles. For footnotes in Tables use Helvetica (or Arial) 9 point font and place these immediately below the Table.

Contact information (institution where the work was carried out and mailing address for the principal author) should be included as footnote 1. This footnote should also include the email address and ORCID for the principal author. Acknowledgment of financial support should be included in footnote 1.

Photographs and 100-word biographies of all authors should be submitted as separate files at the time of the submission of the procedure. The format of the biographies should be similar to those in articles that can be viewed on the orgsyn.org website. Photographs can be accepted in a number of electronic formats, including tiff and jpeg formats.