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Enantioselective Synthesis of Α- and Β- Boc-protected 6-Hydroxy-pyranones: Carbohydrate Building Blocks
Sumit O. Bajaj, Jamison R. Farnsworth and George A. O’Doherty
Org. Synth. 2014, 91, 338
DOI: 10.15227/orgsyn.091.0338
Checked by: Heemal Dhanjee, Michael T. Tudesco, and John L. Wood

Reaction scheme
Ramajeyam Selvaraj, Srinivasa R. Chintala, Michael T. Taylor and Joseph M. Fox
Org. Synth. 2014, 91, 322
DOI: 10.15227/orgsyn.091.0322
Checked by: Jonathan Ruchti and Erick M. Carreira

Reaction scheme
Iron-Catalyzed Selective Conjugate Addition of Aryl Grignard Reagents to 2,4-Alkadienoates: tert-Butyl (Z)-5-Phenyl-3-hexenoate
Takeshi Hata, Hideyuki Goto, Tomofumi Yokomizo, and Hirokazu Urabe
Org. Synth. 2014, 91, 307
DOI: 10.15227/orgsyn.091.0307
Checked by: Liangbing Fu and Huw M. L. Davies

Reaction scheme
Enantioselective Preparation of (S)-5-Oxo-5,6-dihydro-2H-pyran-2-yl Benzoate
Tamas Benkovics, Adrian Ortiz, Zhiwei Guo, Animesh Goswami and Prashant Deshpande
Org. Synth. 2014, 91, 293
DOI: 10.15227/orgsyn.091.0293
Checked by: Magnus C. Eriksson, Suresh R. Kapadia and Chris H. Senanayake

Reaction scheme
Synthesis of 2,3-Disubstituted Benzofurans by the Palladium-Catalyzed Coupling of 2-Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization: 3-Iodo-2-phenylbenzofuran
Tuanli Yao, Dawei Yue, and Richard C. Larock
Org. Synth. 2014, 91, 283
DOI: 10.15227/orgsyn.091.0283
Checked by: Michael Rombola and Viresh H. Rawal

Reaction scheme
Indium-Catalyzed Heteroaryl–Heteroaryl Bond Formation through Nucleophilic Aromatic Substitution: Preparation of 2-Methyl-3-(thien-2-yl)-1H-indole
Yuta Nagase and Teruhisa Tsuchimoto
Org. Synth. 2014, 91, 273
DOI: 10.15227/orgsyn.091.0273
Checked by: Joyce Leung and John Wood

Reaction scheme
Ni-catalyzed Reductive Cleavage of Methyl 3-Methoxy-2-Naphthoate
Josep Cornella, Cayetana Zarate, and Ruben Martin
Org. Synth. 2014, 91, 260
DOI: 10.15227/orgsyn.091.0260
Checked by: Hande Gunduz, Richard P. Loach, and Mohammad Movassaghi

Reaction scheme
Discussion Addendum for: Formation of γ-Keto Esters from β-Keto Esters: Methyl 5,5-dimethyl-4-oxohexanoate
Yashoda M. D. Bhogadhi and Charles K. Zercher
Org. Synth. 2014, 91, 248
DOI: 10.15227/orgsyn.091.0248
Original Article: Org. Synth. 2002, 79, 146

Reaction scheme
Preparation of (R)-4-Cyclohexyl-2,3-butadien-1-ol
Juntao Ye and Shengming Ma
Org. Synth. 2014, 91, 233
DOI: 10.15227/orgsyn.091.0233
Checked by: Mingyao Wu and Dawei Ma

Reaction scheme
Synthesis of 1,3-Dimethyl-3-(p-tolyl)-1H-pyrrolo[3,2-c]pyridin-2(3H)-one by Cu(II)-Mediated Direct Oxidative Coupling
Chandan Dey and E. Peter Kündig
Org. Synth. 2014, 91, 221
DOI: 10.15227/orgsyn.091.0221
Checked by: Yen-Ku Wu and Viresh H. Rawal

Reaction scheme
Synthesis of Tetrasubstituted 1H-Pyrazoles by Copper-mediated Coupling of Enaminones with Nitriles
Mamta Suri and Frank Glorius
Org. Synth. 2014, 91, 211
DOI: 10.15227/orgsyn.091.0211
Checked by: Lan-Ting Xu and Dawei Ma

Reaction scheme
Sodium Methoxide-Catalyzed Direct Amidation of Esters
Kazushi Agura, Takashi Ohshima, Yukiko Hayashi and Kazushi Mashima
Org. Synth. 2014, 91, 201
DOI: 10.15227/orgsyn.091.0201
Checked by: Mengyang Fan and Dawei Ma

Reaction scheme
Synthesis of 4,5-Disubstituted 2-aminothiazoles from α,β-Unsaturated Ketones: Preparation of 5-Benzyl-4-methyl-2-aminothiazolium Hydrochloride Salt
Antonio Bermejo Gómez, Nanna Ahlsten, Ana E. Platero-Prats and Belén Martín-Matute
Org. Synth. 2014, 91, 185
DOI: 10.15227/orgsyn.091.0185
Checked by: Michael T. Tudesco and John L. Wood

Reaction scheme
Enantioselective Organocatalytic α-Arylation of Aldehydes
Pernille H. Poulsen, Mette Overgaard, Kim L. Jensen and Karl Anker Jørgensen
Org. Synth. 2014, 91, 175
DOI: 10.15227/orgsyn.091.0175
Checked by: Yu-Peng He and Dawei Ma

Reaction scheme
Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor: Ethyl 1-Benzyl-trans-5-(trifluoromethyl)pyrrolidine-3-carboxylate
Daniel M. Allwood, Duncan L. Browne and Steven V. Ley
Org. Synth. 2014, 91, 162
DOI: 10.15227/orgsyn.091.0162
Checked by: Hannah E. Peterlin, Neil Languille and Margaret Faul

Reaction scheme
Enantioselective Rhodium-Catalyzed [2+2+2] Cycloaddition of Pentenyl Isocyanate and 4-Ethynylanisole: Preparation and Use of Taddol-pyrrolidine Phosphoramidite
Kevin M. Oberg, Timothy J. Martin, Mark Emil Oinen, Derek M. Dalton, Rebecca Keller Friedman, Jamie M. Neely, and Tomislav Rovis
Org. Synth. 2014, 91, 150
DOI: 10.15227/orgsyn.091.0150
Checked by: Yiyang Liu and Brian M. Stoltz

Reaction scheme
One-pot Preparation of (S)-N-[(S)-1-Hydroxy-4-methyl-1,1-diphenylpentan-2-yl]pyrrolidine-2-carboxamide from L-Proline
Wacharee Harnying, Nongnaphat Duangdee, and Albrecht Berkessel
Org. Synth. 2014, 91, 137
DOI: 10.15227/orgsyn.091.0137
Checked by: Takahiro Sakai and Keisuke Suzuki

Reaction scheme
DABCO-bis(sulfur dioxide), DABSO, as an easy-to-handle source of SO2: Sulfonamide preparation
Edward J. Emmett and Michael C. Willis
Org. Synth. 2014, 91, 125
DOI: 10.15227/orgsyn.091.0125
Checked by: Changming Qin and Huw M. L. Davies

Reaction scheme
Preparation of Alkanesulfonyl Chlorides from S-Alkyl Isothiourea Salts via N-Chlorosuccinimide Mediated Oxidative Chlorosulfonation
Zhanhui Yang and Jiaxi Xu
Org. Synth. 2014, 91, 116
DOI: 10.15227/orgsyn.091.0116
Checked by: Miika Karjomaa, Yoichi Hirano, and Keisuke Suzuki

Reaction scheme
Synthesis of Arylboronic Pinacol Esters from Corresponding Arylamines
Di Qiu, He Meng, Liang Jin, Shengbo Tang, Shuai Wang, Fangyang Mo, Yan Zhang and Jianbo Wang
Org. Synth. 2014, 91, 106
DOI: 10.15227/orgsyn.091.0106
Checked by: Austin Smith and Margaret Faul

Reaction scheme
Preparation of 5-Hydroxycyclopentenones Via Conjugate Addition-Initiated Nazarov Cyclization
Joshua L. Brooks, Yu-Wen Huang, and Alison J. Frontier
Org. Synth. 2014, 91, 93
DOI: 10.15227/orgsyn.091.0093
Checked by: Raffael Vorberg and Erick M. Carreira

Reaction scheme
Cross-Coupling of Alkenyl/Aryl Carboxylates with Grgnard Reagents via Fe-Catalyzed C-O Bond Activation
Bi-Jie Li, Xi-Sha Zhang and Zhang-Jie Shi
Org. Synth. 2014, 91, 83
DOI: 10.15227/orgsyn.091.0083
Checked by: Heemal Dhanjee and John L. Wood

Reaction scheme
Palladium-catalyzed 1,4-Addition of Terminal Alkynes to Conjugated Enones
Feng Zhou, Liang Chen and Chao-Jun Li
Org. Synth. 2014, 91, 72
DOI: 10.15227/orgsyn.091.0072
Checked by: Lan-Ting Xu and Dawei Ma

Reaction scheme
Synthesis of Alkynyliodonium Salts: Preparation of Phenyl(phenylethynyl)iodonium Trifluoroacetate
Luke I. Dixon, Michael A. Carroll, George J. Ellames and Thomas J. Gregson
Org. Synth. 2014, 91, 60
DOI: 10.15227/orgsyn.091.0060
Checked by: David M. Guptill and Huw M. L. Davies

Reaction scheme
Rhodium-Catalyzed Direct Amination of Arene C-H Bonds Using Azides as the Nitrogen Source
Sae Hume Park, Yoonsu Park, and Sukbok Chang
Org. Synth. 2014, 91, 52
DOI: 10.15227/orgsyn.091.0052
Checked by: Kazuma Amaike, Kolby Lyn White, and Mohammad Movassaghi

Reaction scheme
Pd-Catalyzed External-CO-Free Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate
Hideyuki Konishi, Tsuyoshi Ueda, and Kei Manabe
Org. Synth. 2014, 91, 39
DOI: 10.15227/orgsyn.091.0039
Checked by: Jennifer Ciesielski and Erick Carreira

Reaction scheme
N-Carboxylated-2-substituted Indoles and 2,3-Disubstituted-2,3-dihydro-4-quinolones from 2-Alkynylbenzamides
Noriko Okamoto, Kei Takeda, and Reiko Yanada
Org. Synth. 2014, 91, 27
DOI: 10.15227/orgsyn.091.0027
Checked by: Hang Chu and Viresh H. Rawal

Reaction scheme
Discussion Addendum for: Practical Synthesis of Novel Chiral Allenamides: (R)-4-Phenyl-3-(1,2-propadienyl)oxazolidin-2-one
Yong-Chua Teo and Richard P. Hsung
Org. Synth. 2014, 91, 12
DOI: 10.15227/orgsyn.091.0012
Original Article: Org. Synth. 2005, 81, 147

Reaction scheme
Discussion Addendum for: Resolution of 1,1’-Bi-2-Naphthol; (R)-(+)- and (S)-(-)-2,2’-Bis(diphenylphosphino)-1,1’-binaphthyl (BINAP)
David L. Hughes
Org. Synth. 2014, 91, 1
DOI: 10.15227/orgsyn.091.0001

Reaction scheme

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All procedures and characterization data in OrgSyn are peer-reviewed and checked for reproducibility in the laboratory of a member of the Board of Editors