Org. Synth. 1969, 49, 50
DOI: 10.15227/orgsyn.049.0050
3,3'-DIHYDROXYBIPHENYL
[m,m'-Biphenol]
Submitted by J. F. W. McOmie and D. E. West
1.
Checked by J. E. Hiatt and K. B. Wiberg.
1. Procedure
3,3'-Dimethoxybiphenyl2 (8 g., 0.037 mole) is dissolved in
120 ml. of methylene chloride in a
250-ml. conical flask, and the flask is placed in an
acetone-dry ice bath at −80°. The flask is fitted with an
air condenser. A solution of
15.9 g. (6.0 ml., 0.063 mole) of boron tribromide (Note 1),
(Note 2) in
40 ml. of methylene chloride (Note 3),
(Note 4) is added carefully to the stirred solution through the condenser. When the addition is complete, a
calcium chloride tube is fitted to the top of the air condenser in order to protect the reaction mixture from moisture. As the solution of
boron tribromide is added, a white precipitate is formed. The reaction mixture is allowed to attain room temperature overnight with stirring, when a clear, brownish yellow solution is obtained. The reaction mixture is then hydrolyzed by careful shaking with 130 ml. of water, thus precipitating a white solid which is dissolved by the addition of
500 ml. of ether. The organic layer is separated and extracted with
240 ml. of 2N sodium hydroxide; the alkaline extract is neutralized with dilute
hydrochloric acid, extracted with
300 ml. of ether, and the
ether extract is dried over anhydrous
magnesium sulfate. On removal of the
ether under reduced pressure, a brownish yellow oil remains which soon crystallizes to give an off-white solid; this is recrystallized twice from hot
benzene, the first time with the addition of charcoal, and gives
3,3'-dihydroxybiphenyl as white needles with a pinkish tint, m.p.
126–127° (Note 5). The yield is
5.4–6.0 g. (
77–86%).
2. Notes
1.
Boron tribromide of 99.9% purity, from Koch-Light Laboratories Ltd., Colnbrook, Bucks, England, was used.
2.
Boron tribromide is a heavy, colorless liquid (
d = 2.6) when pure but begins to decompose on exposure to light, liberating free
bromine. It fumes vigorously in air, being rapidly hydrolyzed to
boric acid, with the evolution of considerable heat.
3.
Demethylation reactions proceed equally well using dry
n-pentane or dry
methylene chloride as the solvent for both the
ether and the
boron tribromide;
methylene chloride, having by far the more powerful solvent action, is to be preferred.
4.
When making up the solution of
boron tribromide in
methylene chloride, it has been found best to stand the vessel containing the solvent in an acetone-dry ice bath at −80° and to add the required amount (it is difficult to measure accurately) to the
methylene chloride as rapidly as possible.
5.
In order to obtain a perfectly white product, recrystallization from water is necessary;
3,4 prismatic needles several centimeters long are obtained. The compound is moderately soluble in boiling water and slightly soluble in cold water.
3. Discussion
The above preparation of
3,3'-dihydroxybiphenyl is a good example of the utility of
boron tribromide for the cleavage of aryl methyl ethers; it is based on the method of McOmie, Watts, and West.
5 3,3'-Dihydroxybiphenyl has been prepared previously by diazotization
3 of
3,3'-diaminobiphenyl and subsequent boiling with water, by the fusion of
biphenyl-3,3'-disulfonic acid with
potassium hydroxide,
6 and by heating
3,3'-dimethoxybiphenyl with
hydriodic acid.
4Almost all the methods previously employed
7 for the demethylation of aromatic methyl ethers have involved fairly high temperatures,
e.g., hydrogen halides in water or
acetic acid at reflux temperature, whereas the present method is effective at, or well below, room temperature although in a few cases it has been found necessary to boil the solution (b.p. of
methylene chloride,
40°).
Boron tribromide does not effect cleavage of methylenedioxy groups nor of diphenyl ethers. It can be used for the demethylation of aryl methyl ethers in the presence of many functional groups without affecting these.
5 It is especially valuable for the demethylation of iodinated ethers
5 and of methoxy biphenylenes
8 where the usual reagents are either ineffective or else cause decomposition.
Boron tribromide was the reagent of choice for the final (demethylation) step in the synthesis of the naturally occurring macrolide, Zearalenone.
9
Appendix
Chemical Abstracts Nomenclature (Collective Index Number);
(Registry Number)
m,m'-Biphenol
hydrochloric acid (7647-01-0)
acetic acid (64-19-7)
Benzene (71-43-2)
ether (60-29-7)
sodium hydroxide (1310-73-2)
bromine (7726-95-6)
potassium hydroxide (1310-58-3)
hydriodic acid (10034-85-2)
n-PENTANE (109-66-0)
methylene chloride (75-09-2)
boric acid (10043-35-3)
magnesium sulfate (7487-88-9)
boron tribromide (10294-33-4)
3,3'-DIMETHOXYBIPHENYL (6161-50-8)
3,3'-dihydroxybiphenyl (612-76-0)
3,3'-diaminobiphenyl
biphenyl-3,3'-disulfonic acid
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