Org. Synth. 1961, 41, 38
DOI: 10.15227/orgsyn.041.0038
1,6-DIOXO-8a-METHYL-1,2,3,4,6,7,8,8a-OCTAHYDRONAPHTHALENE
[1,6-Naphthalenedione, 1,2,3,4,6,7,8,8a-octahydro-8a-methyl-]
Submitted by S. Ramachandran and Melvin S. Newman
1.
Checked by Max Tishler, G. A. Stein, and G. Lindberg.
1. Procedure
A mixture of 63.1 g. (0.5 mole) of 2-methyl-1,3-cyclohexanedione (Note 1), 52.6 g. (0.75 mole) of methyl vinyl ketone (Note 2), about 0.25 g. (3 pellets) of potassium hydroxide, and 250 ml. of absolute methanol is placed in a 500-ml. round-bottomed flask fitted with a reflux condenser and a drying tube (Note 3). The mixture is heated under reflux for 3 hours, and the dione gradually goes into solution. At the end of this period, methanol and the excess methyl vinyl ketone are removed by distillation under reduced pressure (Note 4) and (Note 5). The residual liquid is dissolved in 250 ml. of benzene, a Dean-Stark phase-separating head is attached, and 20 ml. of solvent is removed by distillation at atmospheric pressure to remove traces of water and methanol. The solution is cooled well below the boiling point, 3 ml. of pyrrolidine is added (Note 6) and the mixture held at reflux for about 30 minutes, during which time about 9 ml. of water collects in the trap. Refluxing is continued for an additional 15 minutes after the separation of water ceases. The water collected is removed, and then 50 ml. of solvent is distilled. The reddish reaction mixture is cooled to room temperature and diluted with 150 ml. of ether. This solution is washed with 100 ml. of distilled water containing 15 ml. of 10% hydrochloric acid and 100 ml. of water. The aqueous extracts are extracted with 50 ml. of ether (Note 7), and the combined organic layers are washed with three 100-ml. portions of water, then with saturated salt solution and dried over magnesium sulfate. The solvents are then removed, and on distillation of the residue (82–85 g.) (Note 8) at 0.5–1.0 mm. (Note 9) the material, b.p. 117–145°, is collected and diluted with 5 ml. of ether. The distillate is placed overnight in a refrigerator, the resulting crystals are then collected by rapid filtration and washed with about 25 ml. of cold ether (Note 10) and (Note 11). The first crop of diketone weighs 50–53 g. and is colorless. The combined mother liquors are redistilled to obtain a further 4–6 g. of crystalline product. A yield of 56–58 g. (63–65% based on dione) of 1,6-dioxo-8a-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalene, m.p. 47–50°, suitable for most other purposes, is obtained (Note 12).
2. Notes
1.
The
2-methyl-1,3-cyclohexanedione was prepared by the method described by Mekler et al., this volume,
p. 743.
2.
Technical grade methyl vinyl ketone supplied by Matheson, Coleman and Bell Co., Cincinnati, Ohio, was used without further purification.
3.
The checkers found that stirring during reflux and concentration and in the cyclization step was advantageous.
4.
The submitters report that the intermediate
2-methyl-2-(3'-oxobutyl)-1,3-cyclohexanedione can be isolated in
85% yield
2 at this point if desired.
5.
The checkers removed
methanol and
methyl vinyl ketone at 650 mm. pressure with a
water bath at 70°.
6.
On adding
pyrrolidine an exothermic reaction occurs rapidly. Cooling is needed to prevent too rapid a reaction. The submitters report that
piperidine may be used in place of
pyrrolidine.
7.
The checkers extracted the aqueous extracts twice with
75-ml. portions of ether.
8.
The checkers found the residual weights to amount to
87–100 g.9.
The checkers used a
saddle-packed 5-in. column and found b.p.
137–150°/0.6–0.7 mm.;
123–150°/0.2–0.5 mm.; and
132–141°/0.5–0.8 mm.10.
A successful crystallization yields relatively large crystals which may be rapidly filtered and washed with
ether with little loss. If fine crystals are obtained, it is preferable to redissolve and allow the material to crystallize again.
11.
Because of the high solubility in
ether (1 g. per 2.5 ml. at room temperature), the checkers washed the product with
hexane (b.p.
60–71°).
12.
Purer product, m.p.
48.6–50.0°, may be obtained by crystallization from
ether.
3. Discussion
1,6-Dioxo-8a-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalene has been obtained through the reaction of
2-methyl-1,3-cyclohexanedione with
acetonedicarboxylic acid and
formaldehyde,
3 4-diethylamino-2-butanone methiodide,
3 pyridine and
4-diethylamino-2-butanone,
4 triethylamine and
4-diethylamino-2-butanone,
5 and by cyclization of
2-methyl-2-(3-oxobutyl)-1,3-cyclohexanedione using either
aluminum tert-butoxide or
piperidine phosphate as catalyst.
6,7
4. Merits of Preparation
1,6-Dioxo-8a-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalene has been employed as an intermediate in the synthesis of terpenes
8,9 and in the projected synthesis of steroids.
4,10
This preparation is referenced from:
Appendix
Chemical Abstracts Nomenclature (Collective Index Number);
(Registry Number)
hydrochloric acid (7647-01-0)
Benzene (71-43-2)
methanol (67-56-1)
ether (60-29-7)
Acetonedicarboxylic acid
formaldehyde (50-00-0)
pyridine (110-86-1)
potassium hydroxide (1310-58-3)
piperidine (110-89-4)
4-diethylamino-2-butanone (3299-38-5)
magnesium sulfate (7487-88-9)
pyrrolidine (123-75-1)
hexane (110-54-3)
methyl vinyl ketone (78-94-4)
triethylamine (121-44-8)
1,6-DIOXO-8a-METHYL-1,2,3,4,6,7,8,8a-OCTAHYDRONAPHTHALENE,
1,6-Naphthalenedione, 1,2,3,4,6,7,8,8a-octahydro-8a-methyl- (20007-72-1)
2-Methyl-1,3-cyclohexanedione (1193-55-1)
2-Methyl-2-(3-oxobutyl)-1,3-cyclohexanedione (5073-65-4)
piperidine phosphate
ALUMINUM tert-BUTOXIDE
4-diethylamino-2-butanone methiodide
Copyright © 1921-, Organic Syntheses, Inc. All Rights Reserved